Endogentamox

Description

Composition: 

Each 1 ml contains: 

Amoxicillin (as Trihydrate) : 150 mg 

Gentamicin (as  Sulphate ) : 40 mg  

 Properties: 

• The combination of amoxicillin and gentamicin acts synergistically against a wide range of infections caused by both Gram-positive (Staphylococcus, Streptococcus and Corynebacterium spp.) and Gram-negative (E. coli, Pasteurella, Salmonella and Pseudomonas spp.) bacteria in cattle, horses, sheep and goats.  
• Amoxicillin inhibits mainly in Gram-positive bacteria the cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall. 
• Gentamicin binds to the 30S subunit of the ribosome of mainly Gram-negative bacteria, thereby interrupting protein synthesis.  

• The combination has less resistance and larger antimicrobial spectrum compared to the two antibiotics separately. 

 Indications: 

It is indicated for the treatment of gastrointestinal, respiratory and intra-mammary infections caused by bacteria sensitive to the combination 

• Cattle: Pneumonia, Diarrhea, Bacterial enteritis, Mastitis, Metritis and Cutaneous abscesses.  

• Horses: Pneumonia, Diarrhea, Bacterial enteritis, Genito-urinary infections, Strangles, cutaneous abscesses and Foot infections.  
• Sheep and Goats: Pneumonia, Diarrhea, Bacterial enteritis Pasteurellosis and Colibacillosis.   

Dosage and administration: 

By intramuscular injection
General dose: 1 ml / 10 kg body weight for 3 days. 

• Cattle: 30-40 ml / animal / day 
• Claves: 10-15 ml / animal / day 
• Horses: 30-50 ml / animal / day 
• Foals: 5-15 ml / animal / day 
• Sheep and Goats: 5-10 ml / animal / day   
• Lambs and Kids: 1-5 ml / animal / day   

* When large volumes are administered, it is advisable to inject the volume at two different sites to better absorption. 

 Contraindications: 

• Administration to animals with a seriously impaired liver and/or renal function.  
• Concurrent administration of tetracyclines, chloramphenicol, macrolides and lincosamides.
  Concurrent administration of nephrotoxic compounds. 

Warnings: 

• Hypersensitivity towards amoxicillin or gentamicin may occur 

• This product contains a mineral oil based compound, it may cause severe pain and inflammation in the case of accidental self- injection clean and disinfect the wound immediately and see a doctor. 

 Withdrawal period: 

• Meat from treated animals shouldn’t be used during treatment and within 30 days from the last treatment. 

• Milk from treated animals shouldn’t be used during treatment and within 2 days from the last treatment. 

 Storage:  

Store at a temperature below 30˚C